Cisplatin pharmacokinetic
WebDec 15, 2012 · Abstract Purpose: To evaluate cisplatin (CDDP) pharmacokinetics after its intravenous (IV) or intrahepatic arterial administration (IHA) in healthy pigs with or without embolization by absorbable gelatine. WebMar 1, 1998 · The pharmacokinetics[PK] of cisplatin are complicated. It is demonstrated that the analysis of PK for free platinum is appropriate to predict the pharmacodynamic [PD] …
Cisplatin pharmacokinetic
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WebJan 16, 2016 · Pharmacokinetic interactions were evaluated.Methods Plasma pazopanib and ultrafilterable cisplatin concentrations were obtained in 32 patients treated according to four levels of dose corresponding to 200, 400 or 600 mg daily dose of pazopanib and 60 or 75 mg/m2 of cisplatin. Two sequences of treatment… View on Springer ncbi.nlm.nih.gov WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …
WebJan 13, 2011 · Cisplatin is one of the most effective chemotherapeutic agents against many forms of cancer including testicular, bladder, head and neck, ovarian, breast, lung, prostate, and refractory non-Hodgkin’s lymphomas ( 2, 3 ). WebCisplatin and platinum pharmacokinetics during hyperthermic isolated limb perfusion for human tumours of the extremities Br J Cancer. 1992 Jun;65(6):898-902. doi: 10.1038/bjc.1992.188. Authors H J Guchelaar 1 , H J Hoekstra, E G de Vries, D R Uges, J W Oosterhuis, H Schraffordt Koops. Affiliation 1 Department of ...
WebMethods: Pharmacokinetic and demographic data were collected from 32 adult patients (20 males/12 females, age range 47-76 years) receiving 30-min infusions … WebPharmacokinetics of cis-diammine-1,1-cyclobutane dicarboxylate platinum (II) in patients with normal and impaired renal function. In vitro studies with plasma and urine demonstrated that, in contrast to cisplatin, CBDCA is a stable complex [t 1/2 - 37 degrees; plasma, 30 hr, and urine, 20 to 460 hr].
WebDec 1, 1992 · The pharmacokinetic profile of vinorelbine is often described as a 3-compartment model characterised by a long terminal half-life that varies between 20 and 40 hours and a large apparent volume of distribution (Vd) of around 70 L/kg. 86 Pulmonary distribution of vinorelbine in patients with non-small-cell lung cancer D. Levêque, E. Quoix,
WebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In … highways closed in floridaWebJan 25, 2008 · For the cisplatin pharmacokinetic studies, the measured absorbance values for the 10 mice receiving cisplatin only were described with a one-compartment pharmacokinetic model. The measured absorbance values at 6 h for the two mice that received STS together with cisplatin were compared with the prediction for the model. … small town at nightWebAug 20, 2024 · Pharmacokinetic data were generated to support clinical dosing decisions, with the aim of adequate exposure and minimal toxicity. In the first chemotherapy cycle, 25% of the standard cisplatin dose and 75% of the carboplatin dose, calculated using the pediatric Calvert formula, were administered. highways closed in san antonioWebCISPLATIN Although they are members of the same chemical family, cis- platin is considered to be superior therapy for specifictumor typescomparedwithcarboplatin.Unfortunately,nephrotoxicity is the dose-limiting side effect of this very effective chemother- apeutic agent (17–19). small town attractions in missouriWebJan 16, 2016 · Purpose A phase I study combining daily oral pazopanib and cisplatin (given iv every 3 weeks) was performed in order to determine the maximum tolerated dose of both drugs in combination. Pharmacokinetic interactions were evaluated. Methods Plasma pazopanib and ultrafilterable cisplatin concentrations were obtained in 32 patients … highways common induction loginWebDec 1, 2024 · Methods. In this open-label, randomized, phase III study, newly diagnosed patients with advanced NSCLC were initially randomized (R1, 1:1) to receive first-line treatment with cisplatin 75 mg/m 2 plus docetaxel 75 mg/m 2 (DC75) or 60 mg/m 2 (DC60) for up to 4 cycles. Patients without progression were further randomized (R2, 1:2) to best … highways closuresWebJun 19, 2024 · Cisplatin concentrations were determined in plasma and ultrafiltrate samples collected on each of six cycles of a monotherapy regimen, beginning with a dose of 1.6 mg/kg at 16 days of age. Pharmacokinetic data were analyzed to generate clearance (CL) and area under the curve (AUC 0–∞) for each administration. highways civil engineering