Cspg4-creert2
WebJun 28, 2024 · CSPG4-directed immunotherapy may be approached in several ways, including: (1) antibody-based fusion proteins for the selective delivery of a pro-apoptotic factors such as tumor necrosis factor-related apoptosis-inducing ligand to agonistic death receptors 4 and 5 on the cell surface; and (2) CSPG4-specific immunotoxins which bind … WebApr 30, 2024 · (D) Quantification analysis in EAE Cspg4-CreERT2/Mapt-GFP transgenic mice showed a significant increase in GFP mean intensity after ERβ treatment.
Cspg4-creert2
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WebJul 6, 2024 · Cspg4 CreERT2 mice express the tamoxifen-inducible Cre-recombinase under the control of Cspg4 promoter. Cspg4 CreERT2 mice were used to label cardiac … WebJun 22, 2024 · Coexpression of NG2 and Notch3 in pulmonary pericytes is also confirmed by immunostaining in Pdgfrb-CreERT2 R26-mT/mG and Cspg4-dsRed.T1 reporter mice (Supplementary Fig. 3c, d).
WebJun 26, 2024 · Neuro-glia antigen 2/chondroitin sulfate proteoglycan 4 (NG2/CSPG4, also called MCSP, HMW-MAA, MSK16, MCSPG, MEL-CSPG, or gp240) is a large cell-surface antigen and an unusual cell membrane integral glycoprotein frequently expressed on undifferentiated precursor cells in multiple solid organ cancers, including cancers of the … WebUpon induction, the recombination occurs in the NG2 positive cells (OPCs and pericytes). The membrane-bound GFP (mGFP) is selectively expressed in myelinating OLs, as it is under the control of ...
WebDownload scientific diagram ERβ-ligand treatment induced remyelination during EAE. (A) Representative EM images of ultraresolution axons and myelin in the spinal cords of WT EAE mice treated ... WebJul 6, 2024 · Cspg4 CreERT2 mice were used to label cardiac pericytes during embryonic development and is a validated model to label Cspg4 expressing cells 35 and were …
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WebJan 10, 2024 · CSPG4, also referred to as melanoma-associated chondroitin sulfate proteoglycan (MCSP), high-molecular-weight melanoma-associated antigen (HMW-MAA), or neuron-glial antigen 2 (NG2), was first associated with malignant melanoma and subsequently implicated in the pathology of other solid tumors of different origins, as well … greek fatal flaws listgreek fast food restaurants near meWebCSPG4 is a cell surface proteoglycan regulated by interleukin 11 in human endometrial epithelial cancer cells. the data suggest that CSPG4 inhibition may impair endometrial cancer progression by reducing cancer cell proliferation, migration and potentially epithelial-to-mesenchymal transition. These data suggest the possible involvement of GD3 ... greek father of history xwordWeb39 recombinase driven by the pericyte-specific Cspg4 promoter (TgCspg4-CreERT2) with mice 40 carrying a Cre-responsive reporter gene (tandem dimer Tomato (tdT)) inserted at the 41 ROSA26 locus (ROSAtdT/+). The PClinmice … greek fast food food near meWebNov 17, 2024 · Pdgfrb(BAC)-CreERT2 4, 33 or B6.Cg-Tg(Cspg4-cre/Esr1*) BAkik/J (NG2-CreER TM) BAC transgenic mice 35 were interbred with Rosa26-mTmG Cre reporter mice 34 or Rosa26-YFP Cre reporter mice … flowbite datepicker not workingWebOct 11, 2024 · CSPG4 is a cell surface proteoglycan with oncogenic functions. It recently emerged as a potential target for immunotherapy, including cell therapy based on CSPG4-specific chimeric antigen receptor (CAR)-redirected cytokine-induced killer lymphocytes (CSPG4-CAR.CIKs) in STS. However, expression of CSPG4 is poorly known in STS so far. greek fates mythologyWebJun 14, 2024 · NG2 (nerve/glia antigen-2) is a type I transmembrane glycoprotein and also known as chondroitin sulfate proteoglycan 4. In the parenchyma of the central nervous … greek father of history