Derlin-1 retrotranslocation complex
WebA protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a … WebA protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a …
Derlin-1 retrotranslocation complex
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• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, et al. (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. Webof a retrotranslocation complex seems to occur in at least two steps. An early step involves the targeting of a retrotranslocation polypeptide to Derlin-1 that is not associated with the p97 ATPase. At a later stage, the ATPase joins Derlin-1 to form a larger retrotranslocation complex, which may also contain spe-cific ubiquitin ligases.
WebSynonyms: Derlin1, Derlin1, Derlin 1, DER1, DER-1, DER 1, DERL1_HUMAN. Target Information: The protein encoded by this gene is a member of the derlin family. … WebPredicted to be part of Derlin-1 retrotranslocation complex; Derlin-1-VIMP complex; and Hrd1p ubiquitin ligase ERAD-L complex. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human DERL1 (derlin 1). [provided by Alliance of Genome Resources, Apr 2024] Other designations. derlin-1, Der1-like domain family ...
WebJul 9, 2009 · Derlin-1 associates with potential ERAD substrates in vitro. The proposed function of Derlin-1 is to facilitate the ER associated degradation of a subset of … WebDER1, the yeast ortholog of Derlin-1, was identified from a genetic screen targeting genes that are required for the degradation of soluble ERAD substrates. 280 DER1 is a UPR …
Webubiquitin ligases and facilitates their recruitment to Derlin-1. Dur-ing retrotranslocation, a substrate first interacts with Derlin-1 before p97 and other factors join the complex. These data, to- ... whether the Derlin-1 complex associates with Hrd1, an ER-anchored ubiquitin ligase (E3 ligase) that is required for the ...
WebApr 15, 2015 · (C) Model depicting the role of the ER-resident NEFs Grp170 and Sil1 during CTA1 retrotranslocation. In the ER, CT targets to the ERAD machinery formed by the Hrd1/Sel1L/Derlin-1 complex partly due to the activity of the Sel1L-binding partner ERdj5. This J-protein enables BiP to capture CT by stimulating BiP's intrinsic ATPase activity. bing search open link in new tabWebMay 9, 2024 · Derlin-1-Flag was immunoprecipitated (IP) with an anti-Flag antibody (Ab) affinity gel and analyzed by immunoblotting (IB) with the indicated Abs. Arrowheads, … bing search open in new tabWebDec 10, 2016 · Varicella-zoster virus (VZV) induces abundant autophagy. Of the nine human herpesviruses, the VZV genome is the smallest (~124 kbp), lacking any known inhibitors of autophagy, such as the herpes simplex virus ICP34.5 neurovirulence gene. Therefore, this review assesses the evidence for VZV-induced cellular stress, endoplasmic-reticulum … dababy bottleWebJun 17, 2024 · The proposed retrotranslocation mechanism via a Derlin-1 tetramer has not been tested as extensively and thoroughly as the mechanism of the Der1-Hrd1 complex (Wu et al., 2024). An obvious question is how is the permeability barrier of the ER membrane maintained to prevent the putative Derlin-1 tetramer acting as a calcium leak … bing search opens new browserWebJun 13, 2008 · Depletion of BAP31 reduces the proteasomal degradation of DeltaF508 and permits a significant fraction of the surviving protein to reach the cell surface. Of note, … bing search operators 2021WebTMEM129 is an unconventional C4C4-type RING finger E3 ubiquitin ligase that resides within a complex containing various other ERAD components, including Derlin-1, Derlin-2, VIMP and p97, indicating that TMEM129 is an integral part of the ER-resident dislocation complex mediating US11-induced HLA class I degradation. bing search operators inurlWebDescription: Homo sapiens derlin 1 (DERL1), transcript variant 1, mRNA. (from RefSeq NM_024295) RefSeq Summary (NM_024295): The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER … bing search overload